Diastereoselective Bidirectional C( sp 3 )−H Bond Functionalization of Piperazine Compounds
نویسندگان
چکیده
A highly diastereoselective bidirectional C(sp3)−H bond functionalization of piperazine compounds, triggered by a Lewis acid catalyzed sequential hydride shift/cyclization process, is reported. Catalysts and ligands are key factors that control the diastereoselectivity reaction. The reaction affords product with good yield high diastereoselectivity. Detailed investigation mechanism reveals energy barrier between cis products trans results in products, which have higher generated from act as intermediate products.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2022
ISSN: ['1615-4169', '1615-4150']
DOI: https://doi.org/10.1002/adsc.202101187